Aldosterone and cortisol co-secreting bifunctional adrenal cortical carcinoma: A rare event

Aldosterone and cortisol co-secreting bifunctional adrenal cortical carcinoma: A rare event

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Adrenocortical carcinoma (ACC) co-secreting aldosterone and cortisol is extremely rare.We report the case of a 37-yearold female who presented with paresis and facial puffiness.Evaluation revealed hypertension, hyperglycemia, severe hypokalemia and hyperaldosteronemia with elevated plasma aldosterone to Necklace renin ratio (ARR).Urinary free cortisol estimation showed elevated levels.Computed tomography scan revealed a right adrenal mass.

Radical adrenalectomy specimen revealed ACC (T3N1).Post-operatively, the Bike Units - Dual Sport patient became normotensive and euglycemic with normalization of urinary cortisol and ARR.This case highlights the need for a complete evaluation in patients of hyperaldosteronism if overlapping symptoms of hypercortisolism are encountered, to avoid post-operative adrenal crisis.